Conference 2010:Control Theory/Optimisation Techniques-ICTS Mumbai
International Centre for Theoretical Sciences is organizing a Conference on Application of Control Theory and Optimisation Techniques in Biochemical Pathways
Control theory is concerned with designing strategies that ensure the robust performance of a system by automatically adapting to changes in the environment. Biochemical pathways in the cell are responsible for processing environmental signals, inducing appropriate cellular responses, and regulating internal events such as gene expression. Through elaborate mechanisms, they allow cells and entire organisms to perform their basic functions. The key role played by feedback in life are manifested in the homeostatic control and regulation of biochemical pathways, which break down nutrients and provide the cell with energy and materials, and their appropriate timing in functions. Recent years have witnessed remarkable advances in elucidating the components of cellular pathways and networks of genes. They provide a snapshot of the complete genetic activity of a cell, yet the overall connectivity and functional characteristics are still poorly understood – a fundamental lacuna in understanding their control archiecture. Several mathematical tools based on control-theoretic thinking have already begun making a contribution in the understanding of the robustness and evolvability in designs of real biochemical pathways. Some examples are the theory of monotone input-output systems, feedback control theory, etc. Optimization techniques (Flux Balance Analysis) are being applied to pathways as it is assumed that biological organisms generally optimize there metabolic pathways for growth. Such applications are useful in designing pathways for addressing host-parasite interactions and pathway engineering. This satellite symposium will explore the close analogies between biochemical regulatory networks and engineered automatic control systems. Feedback, which is a central theme in such analogies, and the role of stochasticity, common in intracellular setting, will be explored in connection to fault-tolerant systems in pathways.
At the symposium, internationally known researchers will discuss relevant mathematical foundations and model systems from biology that would enhance interdisciplinary discussions. The emphasis will be on mathematical theory along with their application. This conference precedes the International Congress of Mathematics to be held at Hyderabad (ICM2010).
Date:
Monday 16 August, 2010-Wednesday 18 August, 2010
Venue:
Tata Consultancy Services, Madhapur, Hyderabad
Contact info:
Dr. Somdatta Sinha
Scientist & Group Leader
Mathematical & Computational Biology
Centre for Cellular & Molecular Biology,
Uppal Road, Hyderabad 500007, INDIA
Phone: +91 40 27192588
Fax: +91 40 27160591; 27160311
Telephone – 914027192588
Email – somdattasinha@gmail.com
Source:
http://www.icts.res.in/program/Biochem
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